The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis

The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis

BackgroundBitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis (CRS). Quinine is a bitter compound that is an a...

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Bibliographic Details
Main Authors: Alan D. Workman, Ivy W. Maina, Steven G. Brooks, Michael A. Kohanski, Beverly J. Cowart, Corrine Mansfield, David W. Kennedy, James N. Palmer, Nithin D. Adappa, Danielle R. Reed, Robert J. Lee, Noam A. Cohen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
quinine
taste receptor family 2
T1R
innate immunity
chronic rhinosinusitis
taste test
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00624/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00624/full

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