The Intolerance of Regulatory Sequence to Genetic Variation Predicts Gene Dosage Sensitivity.
Noncoding sequence contains pathogenic mutations. Yet, compared with mutations in protein-coding sequence, pathogenic regulatory mutations are notoriously difficult to recognize. Most fundamentally, we are not yet adept at recognizing the sequence stretches in the human genome that are most importan...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-09-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4557908?pdf=render |