Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production

Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production

Increased triglyceride synthesis resulting from enhanced flux of fatty acids into liver is frequently associated with VLDL overproduction. This has led to the common belief that hepatic triglyceride synthesis can directly modulate VLDL production. We used adenoviral vectors containing either murine...

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Bibliographic Details
Main Authors: John S. Millar, Scot J. Stone, Uwe J.F. Tietge, Bryan Tow, Jeffrey T. Billheimer, Jinny S. Wong, Robert L. Hamilton, Robert V. Farese, Jr., Daniel J. Rader
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Journal of Lipid Research
Subjects:
cholesterol
low density lipoprotein
adenovirus
apolipoprotein B
diacylglycerol
acyl-coenzyme A:diacylglycerol transferase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434170

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http://www.sciencedirect.com/science/article/pii/S0022227520434170

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