MAAPER: model-based analysis of alternative polyadenylation using 3′ end-linked reads

MAAPER: model-based analysis of alternative polyadenylation using 3′ end-linked reads

Abstract Most eukaryotic genes express alternative polyadenylation (APA) isoforms. A growing number of RNA sequencing methods, especially those used for single-cell transcriptome analysis, generate reads close to the polyadenylation site (PAS), termed nearSite reads, hence inherently containing info...

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Bibliographic Details
Main Authors: Wei Vivian Li, Dinghai Zheng, Ruijia Wang, Bin Tian
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Genome Biology
Subjects:
Alternative polyadenylation
RNA sequencing
Bioinformatic tool
3′ end reads
Cellular stress
Trophoblasts
Online Access:https://doi.org/10.1186/s13059-021-02429-5

Internet

https://doi.org/10.1186/s13059-021-02429-5

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