Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1–42-mediated toxicity

Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1–42-mediated toxicity

Alzheimer's disease (AD) is the most common cause of dementia. At the pre-symptomatic phase of the disease, the processing of the amyloid precursor protein (APP) produces toxic peptides, called amyloid-β 1–42 (Aβ 1–42). The downstream effects of Aβ 1–42 production are not completely uncovered....

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Bibliographic Details
Main Authors: Debasmita Tripathy, Alice Migazzi, Federica Costa, Alessandro Roncador, Pamela Gatto, Federica Fusco, Lucia Boeri, Diego Albani, J. Leon Juárez-Hernández, Carlo Musio, Laura Colombo, Mario Salmona, M.M. Micha Wilhelmus, Benjamin Drukarch, Maria Pennuto, Manuela Basso
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Transglutaminase 1
Alzheimer's disease
Aβ 1–42 peptides
Neuronal death
Activator protein 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301248

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http://www.sciencedirect.com/science/article/pii/S0969996120301248

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