Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism

Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism

Irinotecan (CPT-11)-induced gastrointestinal toxicity strongly limits its anticancer efficacy. Glycyrrhiza uralensis Fisch., especially flavonoids, has strong anti-inflammatory and immunomodulatory activities. Herein, we investigate the protective effect of the total flavonoids of G. uralensis (TFGU...

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Bibliographic Details
Main Authors: Shi-Jun Yue, Yi-Feng Qin, An Kang, Hui-Juan Tao, Gui-Sheng Zhou, Yan-Yan Chen, Jian-Qin Jiang, Yu-Ping Tang, Jin-Ao Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Glycyrrhiza uralensis
total flavonoids
CPT-11
gut microbiota
metabolomics
uric acid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.628358/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.628358/full

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