Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials.

Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials.

The interferon gamma, enzyme-linked immunospot (IFN-γ ELISpot) assay is widely used to identify viral antigen-specific T cells is frequently employed to quantify T cell responses in HIV vaccine studies. It can be used to define T cell epitope specificities using panels of peptide antigens, but with...

Full description

Bibliographic Details
Main Authors: Andrew Fiore-Gartland, Bryce A Manso, David P Friedrich, Erin E Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C De Rosa, Nicole Frahm, Peter B Gilbert, M Juliana McElrath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4749288?pdf=render

Internet

http://europepmc.org/articles/PMC4749288?pdf=render

Similar Items