CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer

CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer

Cancers reprogram their metabolism to adapt to environmental changes. In this study, we examined the consequences of altered expression of the mitochondrial enzyme carnitine palmitoyl transferase I (CPT1A) in prostate cancer (PCa) cell models. Using transcriptomic and metabolomic analyses, we compar...

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Bibliographic Details
Main Authors: Molishree Joshi, Jihye Kim, Angelo D’Alessandro, Emily Monk, Kimberley Bruce, Hanan Elajaili, Eva Nozik-Grayck, Andrew Goodspeed, James C. Costello, Isabel R. Schlaepfer
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
CPT1A
prostate cancer
fatty acids
serine
androgen response
ROS
Online Access:https://www.mdpi.com/2072-6694/12/11/3431

Internet

https://www.mdpi.com/2072-6694/12/11/3431

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