Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

Memory Inflation Drives Tissue-Resident Memory CD8+ T Cell Maintenance in the Lung After Intranasal Vaccination With Murine Cytomegalovirus

Tissue-resident memory T (TRM) cells provide first-line defense against invading pathogens encountered at barrier sites. In the lungs, TRM cells protect against respiratory infections, but wane more quickly than TRM cells in other tissues. This lack of a sustained TRM population in the lung parenchy...

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Bibliographic Details
Main Authors: Kaitlyn M. Morabito, Tracy J. Ruckwardt, Erez Bar-Haim, Deepika Nair, Syed M. Moin, Alec J. Redwood, David A. Price, Barney S. Graham
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
cytomegalovirus
memory inflation
respiratory syncytial virus
tissue-resident memory
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01861/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01861/full

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