Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit inflammatory and neuropathic pain. In this study, we ex...

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Bibliographic Details
Main Authors: Linlin Zhang, Niccolò Terrando, Zhen-Zhong Xu, Sangsu Bang, Sven-Eric Jordt, William Maixner, Charles N. Serhan, Ru-Rong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
DHA (docosahexaenoic acid)
fPOP (post-operative pain after bone fracture)
omega-3 poly unsaturated fatty acids
orthopedic surgery
post-surgical pain
spinal cord
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00412/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00412/full

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