Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization

Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization

Chronic Chagas disease cardiomyopathy (CCC) is a major cause of heart disease in Latin America and treatment for this condition is unsatisfactory. Here we investigated the effects of BA5, an amide semi-synthetic derivative betulinic acid, in a model of CCC. Mice chronically infected with T. cruzi we...

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Bibliographic Details
Main Authors: Cássio Santana Meira, Emanuelle De Souza Santos, Renan Fernandes do Espírito Santo, Juliana Fraga Vasconcelos, Iasmim Diniz Orge, Carolina Kymie Vasques Nonaka, Breno Cardim Barreto, Alex Cleber Improta Caria, Daniela Nascimento Silva, José Maria Barbosa-Filho, Simone Garcia Macambira, Diogo Rodrigo Magalhães Moreira, Milena Botelho Pereira Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
betulinic acid derivative
immunomodulation
chagas disease
cardiomyopathy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01257/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01257/full

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