Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Sepsis-Induced Acute Kidney Injury by Promoting Mitophagy of Renal Tubular Epithelial Cells via the SIRT1/Parkin Axis

Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Sepsis-Induced Acute Kidney Injury by Promoting Mitophagy of Renal Tubular Epithelial Cells via the SIRT1/Parkin Axis

Sepsis is a common risk factor for acute kidney injury (AKI). Bone marrow-derived mesenchymal stem cells (BMSCs) bear multi-directional differentiation potential. This study explored the role of BMSCs in sepsis-induced AKI (SI-AKI). A rat model of SI-AKI was established through cecal ligation and pe...

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Bibliographic Details
Main Authors: Jun Guo, Rong Wang, Donghai Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Endocrinology
Subjects:
sepsis-induced acute kidney injury
bone marrow mesenchymal stem cell
mitophagy
Parkin
SIRT1
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.639165/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.639165/full

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