The Anti-Wrinkle Mechanism of Melatonin in UVB Treated HaCaT Keratinocytes and Hairless Mice via Inhibition of ROS and Sonic Hedgehog Mediated Inflammatory Proteins

The Anti-Wrinkle Mechanism of Melatonin in UVB Treated HaCaT Keratinocytes and Hairless Mice via Inhibition of ROS and Sonic Hedgehog Mediated Inflammatory Proteins

Though melatonin is known to improve ultraviolet B (UVB)-induced oxidative damage and inflammatory conditions via the blockade of the nuclear factor (NF)-κB, interleukin (IL)-6, there is no report on the anti-wrinkle effect of melatonin to date. Hence in the present study, the anti-wrinkle...

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Bibliographic Details
Main Authors: Eun Kyung Park, Hyo-Jung Lee, Hyemin Lee, Ju-Ha Kim, Jisung Hwang, Ja Il Koo, Sung-Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
UVB
HaCaT keratinocytes
collagen
ROS
hedgehog
Cox-2
MMP-1
Online Access:http://www.mdpi.com/1422-0067/19/7/1995

Internet

http://www.mdpi.com/1422-0067/19/7/1995

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