Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones

Synthesis, Antifungal and Antitumor Activity of Novel (Z)-5-Hetarylmethylidene-1,3-thiazol-4-ones and (Z)-5-Ethylidene-1,3-thiazol-4-ones

New hetaryl- and alkylidenerhodanine derivatives 3a–d, 3e, and 4a–d were prepared from heterocyclic aldehydes 1a–d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a–d and 3e with piperidine or morpholine in THF under reflux, afforded (Z)-5-(hetarylmethylidene)-2-(piperidin-1-yl)t...

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Bibliographic Details
Main Authors: Susana A. Zacchino, Justo Cobo, María Victoria Rodríguez, Manuel Nogueras, Rodrigo Abonia, Jairo Quiroga, Carlos Echeverry, Marcela Raimondi, Juan Ramírez, Alberto Insuasty, Braulio Insuasty
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
antifungal activity
antitumor activity
hetarylmethylidenerhodanine derivatives
piperidine
morpholine
Online Access:http://www.mdpi.com/1420-3049/18/5/5482

Internet

http://www.mdpi.com/1420-3049/18/5/5482

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