A design–build–test cycle using modeling and experiments reveals interdependencies between upper glycolysis and xylose uptake in recombinant S. cerevisiae and improves predictive capabilities of large-scale kinetic models

A design–build–test cycle using modeling and experiments reveals interdependencies between upper glycolysis and xylose uptake in recombinant S. cerevisiae and improves predictive capabilities of large-scale kinetic models

Abstract Background Recent advancements in omics measurement technologies have led to an ever-increasing amount of available experimental data that necessitate systems-oriented methodologies for efficient and systematic integration of data into consistent large-scale kinetic models. These models can...

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Bibliographic Details
Main Authors: Ljubisa Miskovic, Susanne Alff-Tuomala, Keng Cher Soh, Dorothee Barth, Laura Salusjärvi, Juha-Pekka Pitkänen, Laura Ruohonen, Merja Penttilä, Vassily Hatzimanikatis
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Biotechnology for Biofuels
Subjects:
Bioethanol
Metabolic control analysis
Large-scale kinetic models
Hexokinase
HXK2 deletion
Xylose utilization
Online Access:http://link.springer.com/article/10.1186/s13068-017-0838-5

Internet

http://link.springer.com/article/10.1186/s13068-017-0838-5

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