Discrete SARS-CoV-2 antibody titers track with functional humoral stability

Discrete SARS-CoV-2 antibody titers track with functional humoral stability

The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elic...

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Bibliographic Details
Main Authors: Yannic C. Bartsch, Stephanie Fischinger, Sameed M. Siddiqui, Zhilin Chen, Jingyou Yu, Makda Gebre, Caroline Atyeo, Matthew J. Gorman, Alex Lee Zhu, Jaewon Kang, John S. Burke, Matthew Slein, Matthew J. Gluck, Samuel Beger, Yiyuan Hu, Justin Rhee, Eric Petersen, Benjamin Mormann, Michael de St Aubin, Mohammad A. Hasdianda, Guruprasad Jambaulikar, Edward W. Boyer, Pardis C. Sabeti, Dan H. Barouch, Boris D. Julg, Elon R. Musk, Anil S. Menon, Douglas A. Lauffenburger, Eric J. Nilles, Galit Alter
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21336-8
Description
Summary:The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elicited receptor-binding domain (RBD)-specific antibody titers above a certain threshold, suggesting that development of T cell responses to be related to anti-RBD Ab production.
ISSN:2041-1723

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