A Pipeline for Reconstructing Somatic Copy Number Alternation’s Subclonal Population-Based Next-Generation Sequencing Data

A Pipeline for Reconstructing Somatic Copy Number Alternation’s Subclonal Population-Based Next-Generation Sequencing Data

State-of-the-art next-generation sequencing (NGS)-based subclonal reconstruction methods perform poorly on somatic copy number alternations (SCNAs), due to not only it needs to simultaneously estimate the subclonal population frequency and the absolute copy number for each SCNA, but also there exist...

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Bibliographic Details
Main Authors: Yanshuo Chu, Chenxi Nie, Yadong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
somatic copy number alternation
subclonal reconstruction
subclonal frequency
absolute copy number
bias correction
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01374/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01374/full

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