4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation
Abstract Background Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-02-01
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Series: | BMC Chemistry |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13065-019-0533-7 |