Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues

Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues

A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined...

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Bibliographic Details
Main Authors: Yanchao Liang, Zhihui Su, Yao Yao, Na Zhang
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Materials
Subjects:
docetaxel
conjugates
nano-micelles
stability
pH controlled release
Online Access:http://www.mdpi.com/1996-1944/8/2/379

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http://www.mdpi.com/1996-1944/8/2/379

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