Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues
A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-01-01
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Series: | Materials |
Subjects: | |
Online Access: | http://www.mdpi.com/1996-1944/8/2/379 |