An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction

An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction

The small GTPase Rac1 promotes actin polymerization and plays a critical and increasingly appreciated role in the development and plasticity of glutamatergic synapses. Growing evidence suggests that disruption of the Rac1 signaling pathway at glutamatergic synapses contributes to Autism Spectrum Dis...

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Bibliographic Details
Main Authors: Chen Tian, Yuni Kay, Anastasiia Sadybekov, Sadhna Rao, Vsevolod Katritch, Bruce E. Herring
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
intellectual disability
glutamatergic synapse
long-term potentiation (LTP)
Rac1
GTP binding
AMPA receptor
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00223/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00223/full

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