Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond
Current approaches have failed to yield success in the translation of neuroprotective therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous explanations have been put forth in both the pre-clinical and clinical arenas. Operation Brain Trauma Therapy (OBTT),...
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Format: | Article |
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Frontiers Media S.A.
2018-08-01
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Series: | Frontiers in Neurology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00640/full |
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doaj-c981f870a73444de9b3b3084fec2d91d |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Patrick M. Kochanek C. Edward Dixon Stefania Mondello Stefania Mondello Kevin K. K. Wang Audrey Lafrenaye Helen M. Bramlett W. Dalton Dietrich Ronald L. Hayes Deborah A. Shear Janice S. Gilsdorf Michael Catania Samuel M. Poloyac Philip E. Empey Travis C. Jackson John T. Povlishock |
spellingShingle |
Patrick M. Kochanek C. Edward Dixon Stefania Mondello Stefania Mondello Kevin K. K. Wang Audrey Lafrenaye Helen M. Bramlett W. Dalton Dietrich Ronald L. Hayes Deborah A. Shear Janice S. Gilsdorf Michael Catania Samuel M. Poloyac Philip E. Empey Travis C. Jackson John T. Povlishock Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond Frontiers in Neurology biomarker pre-clinical consortium neuroprotection drug screening reproducibility theranostic |
author_facet |
Patrick M. Kochanek C. Edward Dixon Stefania Mondello Stefania Mondello Kevin K. K. Wang Audrey Lafrenaye Helen M. Bramlett W. Dalton Dietrich Ronald L. Hayes Deborah A. Shear Janice S. Gilsdorf Michael Catania Samuel M. Poloyac Philip E. Empey Travis C. Jackson John T. Povlishock |
author_sort |
Patrick M. Kochanek |
title |
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond |
title_short |
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond |
title_full |
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond |
title_fullStr |
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond |
title_full_unstemmed |
Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond |
title_sort |
multi-center pre-clinical consortia to enhance translation of therapies and biomarkers for traumatic brain injury: operation brain trauma therapy and beyond |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-08-01 |
description |
Current approaches have failed to yield success in the translation of neuroprotective therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous explanations have been put forth in both the pre-clinical and clinical arenas. Operation Brain Trauma Therapy (OBTT), a pre-clinical therapy and biomarker screening consortium has, to date, evaluated 10 therapies and assessed three serum biomarkers in nearly 1,500 animals across three rat models and a micro pig model of TBI. OBTT provides a unique platform to exploit heterogeneity of TBI and execute the research needed to identify effective injury specific therapies toward precision medicine. It also represents one of the first multi-center pre-clinical consortia for TBI, and through its work has yielded insight into the challenges and opportunities of this approach. In this review, important concepts related to consortium infrastructure, modeling, therapy selection, dosing and target engagement, outcomes, analytical approaches, reproducibility, and standardization will be discussed, with a focus on strategies to embellish and improve the chances for future success. We also address issues spanning the continuum of care. Linking the findings of optimized pre-clinical consortia to novel clinical trial designs has great potential to help address the barriers in translation and produce successes in both therapy and biomarker development across the field of TBI and beyond. |
topic |
biomarker pre-clinical consortium neuroprotection drug screening reproducibility theranostic |
url |
https://www.frontiersin.org/article/10.3389/fneur.2018.00640/full |
work_keys_str_mv |
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doaj-c981f870a73444de9b3b3084fec2d91d2020-11-24T20:57:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-08-01910.3389/fneur.2018.00640387995Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and BeyondPatrick M. Kochanek0C. Edward Dixon1Stefania Mondello2Stefania Mondello3Kevin K. K. Wang4Audrey Lafrenaye5Helen M. Bramlett6W. Dalton Dietrich7Ronald L. Hayes8Deborah A. Shear9Janice S. Gilsdorf10Michael Catania11Samuel M. Poloyac12Philip E. Empey13Travis C. Jackson14John T. Povlishock15Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesSafar Center for Resuscitation Research, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, ItalyOasi Research Institute (IRCCS), Troina, ItalyProgram for Neuroproteomics and Biomarkers Research, Departments of Psychiatry, Neuroscience, and Chemistry, University of Florida, Gainesville, FL, United StatesDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesDepartment of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United StatesCenter for Innovative Research, Center for Neuroproteomics and Biomarkers Research, Banyan Biomarkers Research, Banyan Biomarkers, Inc., Alachua, FL, United StatesBrain Trauma Neuroprotection and Neurorestoration Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United StatesBrain Trauma Neuroprotection and Neurorestoration Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, United States0Banyan Biomarkers, Inc., San Diego, CA, United States1Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, United States2Department of Pharmacy and Therapeutics, Center for Clinical Pharmaceutical Sciences and the Clinical Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, United StatesSafar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United StatesDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, United StatesCurrent approaches have failed to yield success in the translation of neuroprotective therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous explanations have been put forth in both the pre-clinical and clinical arenas. Operation Brain Trauma Therapy (OBTT), a pre-clinical therapy and biomarker screening consortium has, to date, evaluated 10 therapies and assessed three serum biomarkers in nearly 1,500 animals across three rat models and a micro pig model of TBI. OBTT provides a unique platform to exploit heterogeneity of TBI and execute the research needed to identify effective injury specific therapies toward precision medicine. It also represents one of the first multi-center pre-clinical consortia for TBI, and through its work has yielded insight into the challenges and opportunities of this approach. In this review, important concepts related to consortium infrastructure, modeling, therapy selection, dosing and target engagement, outcomes, analytical approaches, reproducibility, and standardization will be discussed, with a focus on strategies to embellish and improve the chances for future success. We also address issues spanning the continuum of care. Linking the findings of optimized pre-clinical consortia to novel clinical trial designs has great potential to help address the barriers in translation and produce successes in both therapy and biomarker development across the field of TBI and beyond.https://www.frontiersin.org/article/10.3389/fneur.2018.00640/fullbiomarkerpre-clinical consortiumneuroprotectiondrug screeningreproducibilitytheranostic |