Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking

Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking

Abstract Background The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improves glucose homeostasis but it could also trigger direct cardioprotective...

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Bibliographic Details
Main Authors: E. Ramírez, B. Picatoste, A. González-Bris, M. Oteo, F. Cruz, A. Caro-Vadillo, J. Egido, J. Tuñón, M. A. Morcillo, Ó. Lorenzo
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Cardiovascular Diabetology
Subjects:
Diabetic cardiomyopathy
Sitagliptin
GLP-1
GLP-1(9-36)
Glut4
PET
Online Access:http://link.springer.com/article/10.1186/s12933-017-0643-2

Internet

http://link.springer.com/article/10.1186/s12933-017-0643-2

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