Duplication of clostridial binding domains for enhanced macromolecular delivery into neurons

Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an increasing need to develop new molecular systems which can deliver drugs specifically into neurons, non-dividing cells meant to last a human lifeti...

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Bibliographic Details
Main Authors: Charlotte Leese, Rebecca Bresnahan, Ciara Doran, Deniz Simsek, Alexander D. Fellows, Laura Restani, Matteo Caleo, Giampietro Schiavo, Timur Mavlyutov, Tina Henke, Thomas Binz, Bazbek Davletov
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Toxicon: X
Online Access:http://www.sciencedirect.com/science/article/pii/S2590171019300165