Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats

Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats

Epoxyeicosatrienoic acids (EETs) and their analogs have been identified as potent antihypertensive compounds with cardio- and renoprotective actions. Here, we examined the effect of EET-A, an orally active EET analog, and c-AUCB, an inhibitor of the EETs degrading enzyme soluble epoxide hydrolase, o...

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Bibliographic Details
Main Authors: Jaroslav Hrdlička, Jan Neckář, František Papoušek, Zuzana Husková, Soňa Kikerlová, Zdenka Vaňourková, Zdenka Vernerová, Firat Akat, Jana Vašinová, Bruce D. Hammock, Sung Hee Hwang, John D. Imig, John R. Falck, Luděk Červenka, František Kolář
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
epoxyeicosatrienoic acid
soluble epoxide hydrolase
chronic heart failure
hypertension
myocardial infarction
echocardiography
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00159/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00159/full

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