Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels.

Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels.

Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder characterized by unprovoked episodes of fever and inflammation. The associated gene, MEFV (Mediterranean Fever), is expressed primarily by cells of myeloid lineage and encodes the protein pyrin/TRIM20/Marenostrin. The mecha...

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Bibliographic Details
Main Authors: Pamela R Hesker, MyTrang Nguyen, Martina Kovarova, Jenny P-Y Ting, Beverly H Koller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511413?pdf=render

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http://europepmc.org/articles/PMC3511413?pdf=render

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