Designing and constructing a phage display synthesized single domain antibodies library based on camel VHHs frame for screening and identifying humanized TNF-α-specific nanobody

Designing and constructing a phage display synthesized single domain antibodies library based on camel VHHs frame for screening and identifying humanized TNF-α-specific nanobody

Tumor necrosis factor (TNF-α) is an important clinically tested cytokine that could induce autoimmune diseases and inflammation. Therefore, the anti-TNF-α therapy strategy was developed and used therapeutically in various diseases, especially in the cytokine storm associated chimeric antigen recepto...

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Bibliographic Details
Main Authors: Jifan Nie, Xingyuan Ma, Fabiao Hu, Hui Miao, Xin Feng, Peiwen Zhang, Myong Hun Han, Fang You, Yi Yang, Wenlian Zhang, Wenyun Zheng
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Single domain antibodies
Phage display library
Designing and constructing
Humanized TNF-α-specific Nb
Screening and identifyin
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222100113X

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http://www.sciencedirect.com/science/article/pii/S075333222100113X

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