Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease

Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease

Progranulin gene (PGRN) mutations cause ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17 (FTLDU-17). The spectrum of known mutations strongly suggests that neurodegeneration results from a partial loss of PGRN function and leads to the hypothesis that PGRN gene deletions...

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Bibliographic Details
Main Authors: Anne Rovelet-Lecrux, Vincent Deramecourt, Solenn Legallic, Claude-Alain Maurage, Isabelle Le Ber, Alexis Brice, Jean-Charles Lambert, Thierry Frébourg, Didier Hannequin, Florence Pasquier, Dominique Campion
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Neurobiology of Disease
Subjects:
Progranulin
Deletion
Frontotemporal lobar degeneration
Parkinson disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610800051X

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http://www.sciencedirect.com/science/article/pii/S096999610800051X

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