Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice

Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice

Idiopathic pulmonary fibrosis (IPF) is a progressive and usually fatal lung disease that is characterized by fibroblast proliferation and extracellular matrix remodeling, which result in irreversible distortion of the lung’s architecture and the formation of focal fibrous hyperplasia. The molecular...

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Bibliographic Details
Main Authors: Xiaohe Li, Zhun Bi, Shuaishuai Liu, Shaoyan Gao, Yunyao Cui, Kai Huang, Mengying Huang, Jiahe Mao, Lixin Li, Jingjing Gao, Tao Sun, Honggang Zhou, Cheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
cinobufagin
pulmonary fibrosis
fibroblasts
epithelial-mesenchymal transition
TGF-β1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01021/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01021/full

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