Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14

Abstract The KIF14 locus is gained and overexpressed in various malignancies, with prognostic relevance. Its protein product, a mitotic kinesin, accelerates growth of normal mammary epithelial cells in vitro and retinoblastoma tumours in a mouse model, while KIF14 knockdown blocks growth of brain, l...

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Bibliographic Details
Main Authors: Kamakshi Sishtla, Natalie Pitt, Mehdi Shadmand, Michael N. O’Hare, Rania S. Sulaiman, Anthony L. Sinn, Keith Condon, Karen E. Pollok, George E. Sandusky, Timothy W. Corson
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Scientific Reports
Subjects:
Mitotic Kinesin
Fatal Lymphoma
KIF Expression
Protein Regulator Of Cytokinesis 1 (PRC1)
Citron Kinase
Online Access:https://doi.org/10.1038/s41598-018-34603-4

Internet

https://doi.org/10.1038/s41598-018-34603-4

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