The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk

The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk

Alzheimer’s disease (AD) is a progressive neurodegenerative disease. Although it has been studied for years, the pathogenesis of AD is still controversial. Genetic factors may play an important role in pathogenesis, with the apolipoprotein E (APOE) gene among the greatest risk factors for...

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Bibliographic Details
Main Authors: Jialing Fan, Wuhai Tao, Xin Li, He Li, Junying Zhang, Dongfeng Wei, Yaojing Chen, Zhanjun Zhang
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
APOE
cognition
brain structure
brain function
polygenic risk score
Online Access:http://www.mdpi.com/1422-0067/20/5/1177

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http://www.mdpi.com/1422-0067/20/5/1177

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