Interpretation of the consequences of mutations in protein kinases: combined use of bioinformatics and text mining

Protein kinases play a crucial role in a plethora of significant physiological functions and a number of mutations in this superfamily have been reported in the literature to disrupt protein structure and/or function.Computational and experimental research aims to discover the mechanistic connection...

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Bibliographic Details
Main Authors: Jose M.G. Izarzugaza, Martin eKrallinger, Alfonso eValencia
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00323/full