The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response

The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response

The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto u...

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Bibliographic Details
Main Authors: Beatrice Bergström, Christina Lundqvist, Georgios K. Vasileiadis, Hans Carlsten, Olov Ekwall, Anna-Karin H. Ekwall
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
fibroblast-like synoviocytes
inflammation
cytokines
AIRE
interferon response genes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01384/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01384/full

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