Cryptic determinant of α4β7 binding in the V2 loop of HIV-1 gp120.

Cryptic determinant of α4β7 binding in the V2 loop of HIV-1 gp120.

The peptide segment of the second variable loop of HIV-1 spanning positions 166-181 harbors two functionally important sites. The first, spanning positions 179-181, engages the human α4β7 integrin receptor which is involved in T-cell gut-homing and may play a role in human immunodeficiency virus (HI...

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Bibliographic Details
Main Authors: Boonrat Tassaneetrithep, Doreen Tivon, James Swetnam, Nicos Karasavvas, Nelson L Michael, Jerome H Kim, Mary Marovich, Timothy Cardozo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4180765?pdf=render

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http://europepmc.org/articles/PMC4180765?pdf=render

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