Endothelial barrier function is co-regulated at vessel bifurcations by fluid forces and sphingosine-1-phosphate

Endothelial barrier function is co-regulated at vessel bifurcations by fluid forces and sphingosine-1-phosphate

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid mediator of endothelial barrier function. Prior studies have implicated mechanical stimulation due to intravascular laminar shear stress in co-regulating S1P signaling in endothelial cells (ECs). Yet, vascular networks in vivo consist of vess...

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Bibliographic Details
Main Authors: Ehsan Akbari, Griffin B. Spychalski, Miles M. Menyhert, Kaushik K. Rangharajan, Joseph W. Tinapple, Shaurya Prakash, Jonathan W. Song
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomaterials and Biosystems
Subjects:
Vessel permeability
Microfluidic biomimicry
Branched microvessels
Mechanotransduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2666534421000131

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http://www.sciencedirect.com/science/article/pii/S2666534421000131

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