Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

Immune checkpoint inhibitors (ICIs) can block distinct receptors on T cells or tumor cells thus preventing T cell inactivation and tumor immune escape. While the clinical response to treatment with ICIs in cancer patients is impressive, this therapy is often associated with a number of immune-relate...

Full description

Bibliographic Details
Main Authors: Johanna Reul, Janina Frisch, Christine E. Engeland, Frederic B. Thalheimer, Jessica Hartmann, Guy Ungerechts, Christian J. Buchholz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Oncology
Subjects:
antibody gene delivery
tumor targeting
checkpoint inhibition
biodistribution
adeno-associated virus
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00052/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00052/full

Similar Items