C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

C/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation

In ovarian cancer, the mechanism of chemoresistance is a key question. Here, the authors demonstrate that C/EBPβ and DOT1L together increase methylation of H3K79, which upregulates expression of oncogenic genes and drives poor platinum response and poor survival in ovarian cancer.

Bibliographic Details
Main Authors: Dan Liu, Xiao-Xue Zhang, Meng-Chen Li, Can-Hui Cao, Dong-Yi Wan, Bi-Xin Xi, Jia-Hong Tan, Ji Wang, Zong-Yuan Yang, Xin-Xia Feng, Fei Ye, Gang Chen, Peng Wu, Ling Xi, Hui Wang, Jian-Feng Zhou, Zuo-Hua Feng, Ding Ma, Qing-Lei Gao
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03590-5

Internet

https://doi.org/10.1038/s41467-018-03590-5

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