Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer

Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors (statins) may overcome resistance. Proteomic profiling and comparison of radioresistant to rad...

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Bibliographic Details
Main Authors: Natalia Ricco, Amy Flor, Don Wolfgeher, Elena V. Efimova, Aishwarya Ramamurthy, Oliver K. Appelbe, Jacqueline Brinkman, Andrew W. Truman, Michael T. Spiotto, Stephen J. Kron
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Molecular Oncology
Subjects:
DNA damage response
HNSCC
mevalonate pathway
radiation sensitivity
senescence
statin
Online Access:https://doi.org/10.1002/1878-0261.12535

Internet

https://doi.org/10.1002/1878-0261.12535

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