CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation

CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation

Amyloid-β (Aβ) immunization efficiently reduces amyloid plaque load and memory impairment in transgenic mouse models of Alzheimer's disease (AD). Active Aβ immunization has also yielded favorable results in a subset of AD patients. However, a small percentage of patients developed severe asepti...

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Bibliographic Details
Main Authors: D. Obregon, H. Hou, Y. Bai, W.V. Nikolic, T. Mori, Deyan Luo, J. Zeng, J. Ehrhart, F. Fernandez, D. Morgan, B. Giunta, T. Town, J. Tan
Format: Article
Language:English
Published: Elsevier 2008-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
β-Amyloid
Cerebral amyloid angiopathy
Aβ immunization
CD40
CD154
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002239

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http://www.sciencedirect.com/science/article/pii/S0969996107002239

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