The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

Genetic and environmental factors, such as metals, interact to determine neurological traits. We reasoned that interactomes of molecules handling metals in neurons should include novel metal homeostasis pathways. We focused on copper and its transporter ATP7A because ATP7A null mutations cause neuro...

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Bibliographic Details
Main Authors: Heather S Comstra, Jacob McArthy, Samantha Rudin-Rush, Cortnie Hartwig, Avanti Gokhale, Stephanie A Zlatic, Jessica B Blackburn, Erica Werner, Michael Petris, Priya D’Souza, Parinya Panuwet, Dana Boyd Barr, Vladimir Lupashin, Alysia Vrailas-Mortimer, Victor Faundez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
ATP7A
Menkes
copper
neurodegeneration
neurodevelopmental
Golgi
Online Access:https://elifesciences.org/articles/24722

Internet

https://elifesciences.org/articles/24722

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