Metformin Clinical Trial in HPV+ and HPV– Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate

Metformin Clinical Trial in HPV+ and HPV– Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate

Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial complex I and oxidative phosphorylation has been reported to correlate with improved outcomes in head and neck squamous cell carcinoma (HNSCC) and other cancers. This effect is postulated to occur through disruption...

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Bibliographic Details
Main Authors: Joseph M. Curry, Jennifer Johnson, Mehri Mollaee, Patrick Tassone, Dev Amin, Alexander Knops, Diana Whitaker-Menezes, My G. Mahoney, Andrew South, Ulrich Rodeck, Tingting Zhan, Larry Harshyne, Nancy Philp, Adam Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo Martinez-Outschoorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
head and neck cancer
squamous cell carcinoma
metformin
tumor microenvironment
immune infiltrate
HPV
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00436/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00436/full

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