DNA methylation mediates persistent epileptiform activity in vitro and in vivo.

DNA methylation mediates persistent epileptiform activity in vitro and in vivo.

Epilepsy is a chronic brain disorder involving recurring seizures often precipitated by an earlier neuronal insult. The mechanisms that link the transient neuronal insult to the lasting state of epilepsy are unknown. Here we tested the possible role of DNA methylation in mediating long-term inductio...

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Bibliographic Details
Main Authors: Ziv M Machnes, Tony C T Huang, Philip K Y Chang, Raminder Gill, Nicholas Reist, Gabriella Dezsi, Ezgi Ozturk, Francois Charron, Terence J O'Brien, Nigel C Jones, R Anne McKinney, Moshe Szyf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788713?pdf=render

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http://europepmc.org/articles/PMC3788713?pdf=render

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