Bone Marrow Clonogenic Myeloid Progenitors from <i>NPM1</i>-Mutated AML Patients Do Not Harbor the <i>NPM1</i> Mutation: Implication for the Cell-Of-Origin of <i>NPM1+</i> AML

Bone Marrow Clonogenic Myeloid Progenitors from <i>NPM1</i>-Mutated AML Patients Do Not Harbor the <i>NPM1</i> Mutation: Implication for the Cell-Of-Origin of <i>NPM1+</i> AML

The cell-of-origin of <i>NPM1</i>- and <i>FLT3</i>-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML in diag...

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Bibliographic Details
Main Authors: Rafael Diaz de la Guardia, Laura González-Silva, Belén López-Millán, Juan José Rodríguez-Sevilla, Matteo L. Baroni, Clara Bueno, Eduardo Anguita, Susana Vives, Laura Palomo, Helene Lapillonne, Ignacio Varela, Pablo Menendez
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Genes
Subjects:
aml
npm1 mutations
flt3-itd
clonogenic progenitors
colony forming units (cfu)
Online Access:https://www.mdpi.com/2073-4425/11/1/73

Internet

https://www.mdpi.com/2073-4425/11/1/73

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