Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse

Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse

David Bonsall,1 Stuart Black,2 Anita YM Howe,2 Robert Chase,2 Paul Ingravallo,2 Irene Pak,2 Anthony Brown,1 David A Smith,1 Rory Bowden,1 Eleanor Barnes1 On behalf of the STOP HCV Consortium 1Translational Gastroenterology Unit, University of Oxford, Oxford, UK; 2Department of Infectious Diseases, M...

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Bibliographic Details
Main Authors: Bonsall D, Black S, Howe AYM, Chase R, Ingravallo P, Pak I, Brown A, Smith DA, Bowden R, Barnes E
Format: Article
Language:English
Published: Dove Medical Press 2018-08-01
Series:Infection and Drug Resistance
Subjects:
Next-generation sequencing
NS3/4A protease inhibitor
resistance-associated substitution
virologic failure
Online Access:https://www.dovepress.com/characterization-of-hepatitis-c-virus-resistance-to-grazoprevir-reveal-peer-reviewed-article-IDR

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https://www.dovepress.com/characterization-of-hepatitis-c-virus-resistance-to-grazoprevir-reveal-peer-reviewed-article-IDR

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