Cooperation of FGF/MEK/ERK and Wnt/β-catenin pathway regulators to promote the proliferation and pluripotency of mouse embryonic stem cells in serum- and feeder-free conditions

Cooperation of FGF/MEK/ERK and Wnt/β-catenin pathway regulators to promote the proliferation and pluripotency of mouse embryonic stem cells in serum- and feeder-free conditions

Abstract The FGF/MEK/ERK and Wnt/β-catenin signaling pathways have previously been proved to regulate mouse embryonic stem cell (mESCs) function. However, the relationships between these two pathways, especially their different functions on proliferation and pluripotency of mESCs, were rarely mentio...

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Bibliographic Details
Main Authors: Tong Zhang, Huanyun Chen, Yiran Zhou, Wanghong Dong, Haibo Cai, Wen-Song Tan
Format: Article
Language:English
Published: SpringerOpen 2019-04-01
Series:Bioresources and Bioprocessing
Subjects:
mESCs
FGF/MEK/ERK pathway
Wnt/β-catenin pathway
Small molecule regulator
In vitro proliferation
Online Access:http://link.springer.com/article/10.1186/s40643-019-0249-5

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http://link.springer.com/article/10.1186/s40643-019-0249-5

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