Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation

Abstract Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathways through global gene expression profiling revealed that SMA was characteriz...

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Bibliographic Details
Main Authors: Prakasha Kempaiah, Karol Dokladny, Zachary Karim, Evans Raballah, John M Ong’echa, Pope L Moseley, Douglas J Perkins
Format: Article
Language:English
Published: BMC 2016-08-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00130

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http://link.springer.com/article/10.2119/molmed.2016.00130

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