Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill.

Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill.

AUTHOR SUMMARY:Cancer treatment efficacy can be significantly enhanced through the elution of drug from nano-carriers that can temporarily stay in the tumor vasculature. Here we present a relatively simple yet powerful mathematical model that accounts for both spatial and temporal heterogeneities of...

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Bibliographic Details
Main Authors: Zhihui Wang, Romica Kerketta, Yao-Li Chuang, Prashant Dogra, Joseph D Butner, Terisse A Brocato, Armin Day, Rong Xu, Haifa Shen, Eman Simbawa, A S Al-Fhaid, S R Mahmoud, Steven A Curley, Mauro Ferrari, Eugene J Koay, Vittorio Cristini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4902302?pdf=render

Internet

http://europepmc.org/articles/PMC4902302?pdf=render

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