Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents

Phenanthroindolizidines, such as antofine and tylophorine, are a family of natural alkaloids isolated from different species of <i>Asclepiadaceas.</i> They are characterized by interesting biological activities, such as pronounced cytotoxicity against different human cancerous cell lines...

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Bibliographic Details
Main Authors: Ziad Omran, Chris P. Guise, Linwei Chen, Cyril Rauch, Ashraf N. Abdalla, Omeima Abdullah, Ikhlas A. Sindi, Peter M. Fischer, Jeff B. Smaill, Adam V. Patterson, Yuxiu Liu, Qingmin Wang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
phenanthroindolizidine
antofine
tylophorine
hypoxia
prodrugs
solid tumors
Online Access:https://www.mdpi.com/1420-3049/26/11/3327

Internet

https://www.mdpi.com/1420-3049/26/11/3327

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