Hyperglycemia and Renal Mass Ablation Synergistically Augment Albuminuria in the Diabetic Subtotally Nephrectomized Rat: Implications for Modeling Diabetic Nephropathy

Hyperglycemia and Renal Mass Ablation Synergistically Augment Albuminuria in the Diabetic Subtotally Nephrectomized Rat: Implications for Modeling Diabetic Nephropathy

Background/Aims: While experimental models that emulate diabetic nephropathy are valuable tools for elucidating pathogenetic mechanisms and developing novel therapies, existing models imperfectly recapitulate human disease. In diabetes, hyperglycemia and hemodynamic forces act in concert to induce r...

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Bibliographic Details
Main Authors: Li-Hao Chen, Bailey Stead, Suzanne L. Advani, Noreen Yaqoob, Kerri Thai, M. Golam Kabir, Darren A. Yuen, Kim A. Connelly, Richard E. Gilbert, Andrew Advani
Format: Article
Language:English
Published: Karger Publishers 2012-05-01
Series:Nephron Extra
Subjects:
Nephrin
Glomerulosclerosis
Experimental model
Diabetic nephropathy
Subtotal nephrectomy
Streptozotocin
Albuminuria
Glomerular hypertrophy
Online Access:http://www.karger.com/Article/FullText/338272

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http://www.karger.com/Article/FullText/338272

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