Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress
The role of peroxiredoxin (Prx) I as an erythrocyte antioxidantdefense in red blood cells (RBCs) is controversial. Here weinvestigated the function of Prx I by using Prx I–⁄– and Prx I/II–⁄–mice. Prx I–⁄– mice exhibited a normal blood profile. However,Prx I/II–⁄– mice showed more significantly incre...
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Korean Society for Biochemistry and Molecular Biology
2012-10-01
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doaj-c9e3fdf3feb14bc0b95b8ed738662d5b2020-11-25T00:13:08ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2012-10-014510560564Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress Ying-Hao Han1,8,#, Taeho Kwon1,7,#, Sun-Uk Kim1,2,#, Hye-Lin Ha1, Tae-Hoon Lee1,3, Jin-Man Kim4, Eun-Kyeong Jo5, Bo Yeon Kim6, Do Young Yoon7 & Dae-Yeul Yu1,*The role of peroxiredoxin (Prx) I as an erythrocyte antioxidantdefense in red blood cells (RBCs) is controversial. Here weinvestigated the function of Prx I by using Prx I–⁄– and Prx I/II–⁄–mice. Prx I–⁄– mice exhibited a normal blood profile. However,Prx I/II–⁄– mice showed more significantly increased Heinz bodyformation as compared with Prx II–⁄– mice. The clearance rate ofHeinz body-containing RBCs in Prx I–⁄– mice decreasedsignificantly through the treatment of aniline hydrochloride (AH)compared with wild-type mice. Prx I deficiency decreased thephagocytic capacity of macrophage in clearing Heinz bodycontainingRBCs. Our data demonstrate that Prx I deficiency didnot cause hemolytic anemia, but showed that further increasedhemolytic anemia symptoms in Prx II–⁄– mice by attenuatingphagocytic capacity of macrophage in oxidative stress damagedRBCs, suggesting a novel role of Prx I in phagocytosis ofmacrophage.http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0xMCU1RDEyMTAyOTIxMTVfJTI4NTYwLTU2NCUyOUJNQl8xMi0wODIucGRmHeinz bodyHemolytic anemiaMacrophagePeroxiredoxinPhagocytosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying-Hao Han1,8,#, Taeho Kwon1,7,#, Sun-Uk Kim1,2,#, Hye-Lin Ha1, Tae-Hoon Lee1,3, Jin-Man Kim4, Eun-Kyeong Jo5, Bo Yeon Kim6, Do Young Yoon7 & Dae-Yeul Yu1,* |
spellingShingle |
Ying-Hao Han1,8,#, Taeho Kwon1,7,#, Sun-Uk Kim1,2,#, Hye-Lin Ha1, Tae-Hoon Lee1,3, Jin-Man Kim4, Eun-Kyeong Jo5, Bo Yeon Kim6, Do Young Yoon7 & Dae-Yeul Yu1,* Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress BMB Reports Heinz body Hemolytic anemia Macrophage Peroxiredoxin Phagocytosis |
author_facet |
Ying-Hao Han1,8,#, Taeho Kwon1,7,#, Sun-Uk Kim1,2,#, Hye-Lin Ha1, Tae-Hoon Lee1,3, Jin-Man Kim4, Eun-Kyeong Jo5, Bo Yeon Kim6, Do Young Yoon7 & Dae-Yeul Yu1,* |
author_sort |
Ying-Hao Han1,8,#, Taeho Kwon1,7,#, Sun-Uk Kim1,2,#, Hye-Lin Ha1, Tae-Hoon Lee1,3, Jin-Man Kim4, Eun-Kyeong Jo5, Bo Yeon Kim6, Do Young Yoon7 & Dae-Yeul Yu1,* |
title |
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress |
title_short |
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress |
title_full |
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress |
title_fullStr |
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress |
title_full_unstemmed |
Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress |
title_sort |
peroxiredoxin i deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress |
publisher |
Korean Society for Biochemistry and Molecular Biology |
series |
BMB Reports |
issn |
1976-6696 1976-670X |
publishDate |
2012-10-01 |
description |
The role of peroxiredoxin (Prx) I as an erythrocyte antioxidantdefense in red blood cells (RBCs) is controversial. Here weinvestigated the function of Prx I by using Prx I–⁄– and Prx I/II–⁄–mice. Prx I–⁄– mice exhibited a normal blood profile. However,Prx I/II–⁄– mice showed more significantly increased Heinz bodyformation as compared with Prx II–⁄– mice. The clearance rate ofHeinz body-containing RBCs in Prx I–⁄– mice decreasedsignificantly through the treatment of aniline hydrochloride (AH)compared with wild-type mice. Prx I deficiency decreased thephagocytic capacity of macrophage in clearing Heinz bodycontainingRBCs. Our data demonstrate that Prx I deficiency didnot cause hemolytic anemia, but showed that further increasedhemolytic anemia symptoms in Prx II–⁄– mice by attenuatingphagocytic capacity of macrophage in oxidative stress damagedRBCs, suggesting a novel role of Prx I in phagocytosis ofmacrophage. |
topic |
Heinz body Hemolytic anemia Macrophage Peroxiredoxin Phagocytosis |
url |
http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS0xMCU1RDEyMTAyOTIxMTVfJTI4NTYwLTU2NCUyOUJNQl8xMi0wODIucGRm |
work_keys_str_mv |
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1725396314833813504 |