A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease

A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease

Abstract One of remarkable features of sporadic Creutzfeldt-Jakob disease (sCJD) is the great phenotypic variability. Understanding the molecular basis of this variability has important implications for the development of therapeutic approaches. It is well established that, in many cases, phenotypic...

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Bibliographic Details
Main Authors: Satish K. Nemani, Xiangzhu Xiao, Ignazio Cali, Laura Cracco, Gianfranco Puoti, Massimiliano Nigro, Jody Lavrich, Anuradha Bharara Singh, Brian S. Appleby, Valerie L. Sim, Silvio Notari, Witold K. Surewicz, Pierluigi Gambetti
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Acta Neuropathologica Communications
Subjects:
Prion protein allotype
129 M and 129 V proportion
129 M/V polymorphism
Epitope mapping
Mass spectrometry
Online Access:http://link.springer.com/article/10.1186/s40478-020-00966-x

Internet

http://link.springer.com/article/10.1186/s40478-020-00966-x

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